FIGURE

Fig. 5

ID

ZDB-FIG-180927-40

Publication

Karra et al., 2018 - Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish

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Fig. 5

Dependence of vegfaa-induced CM hyperplasia on Notch signaling. (A–D) In situ hybridization for notch1b and deltaC on cardiac sections from cmlc2:CreER;βact2:BS-vegfaa animals 14 dpi with vehicle or tamoxifen. Violet staining indicates expression. (E–H) Maximum-intensity projections of 7 dpf hearts from cmlc2:H2A-EGFP;βact2:BS-vegfaa fish with or without an additional cmlc2:CreER transgene. Animals were first treated with 4-HT, followed by DMSO (n = 9 for Cre⁻ animals and n = 10 for Cre⁺ animals) or DAPT (n = 8 for Cre⁻ animals and n = 9 for Cre⁺ animals). (I) Number of CMs at 7 dpf for treatment groups shown in E–H. Error bars indicate SD (*P < 0.05, **P < 0.01, and ***P < 0.001, Student’s t test). NS, not significant. [Scale bars: A and E, 100 μm (also apply to B–D and F–H, respectively).]

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA