FIGURE

Fig. S1

ID

ZDB-FIG-180823-6

Publication

Guzzolino et al., 2018 - Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish

Other Figures

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Fig. S1

s1pr1 downregulation has a small impact on heart development. (A) Analysis of 72hpf Tg(Myl7:EGFP) embryos injected with MO-s1pr1 or MO-Ct at the reported doses (ng). The percentage of embryos with the indicated heart defects was averaged across multiple independent experiments carried out in double blind. The total number of analyzed embryos were as follows: MO-Ct (0,2ng) n=152, MO-s1pr1 (0.2ng) n=146, MO-Ct (1ng) n=101, MOs1pr1 (1 ng) n=117. T-test p= 0,014. (B) images are representative of hearts showing an enlarged atrium as a consequence of 1 ng MO-s1pr1 injection. Spotted lines highlight the atrium shape. V= ventricle A= atrium .Red scale bar = 100μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	twu34Tg + MO2-s1pr1
Knockdown Reagent:	MO2-s1pr1
Observed In:	heart heart looping
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol