FIGURE

Fig. S6

ID

ZDB-FIG-180105-54

Publication

Smith et al., 2017 - TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone

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Fig. S6

Knockdown of tnfa and tnfr2 causes neural defects.

(A) In Tg(ngn1:egfp) embryos injected with either tnfa or tnfr2 MOs, we observed ectopic axons that did not navigate to the DREZ. (B) Quantification of the number of ngn1⁺ cells per DRG at 72 hpf in wildtype, tnfa and tnfr2 morphants. (C) Quantification of sox10⁺ glia at 96 hpf in wildtype (n = 60 DRG). The tnfa (n = 61 DRG) and tnfr2 morphant (n = 44 DRG) larvae showing the glial ensheathment defect persists to 96 hpf. Scale bar, 25 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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