FIGURE

Fig. 5

ID

ZDB-FIG-171206-76

Publication

Zhang et al., 2017 - Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways

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Fig. 5

The effect of PTS on 6-OHDA-induced dopaminergic (DA) neuron loss in zebrafish.

Zebrafish embryos at one day post fertilization were exposed to indicated concentrations of PTS or nomifensine (Nom, used as a positive control) in the presence or absence of 0.25?mM 6-OHDA for 48?h. Then larvae were fixed for whole mount immunostaining with antibody against tyrosine hydroxylase (TH). (A) Representative morphology of DA neurons in the zebrafish brain. TH⁺ neurons in the diencephalic region are within brackets. (B) Statistical analysis of TH⁺ neurons in each group of ten fish. Values represent the mean?�?SD of at least three independent experiments. Data are expressed as a percentage of the control group. ^###P?<?0.01 versus control (CTL) group, **P?<?0.01 versus 6-OHDA-treated group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: oxidopamine chemical treatment by environment: ginsenoside
Observed In:	diencephalon dopaminergic neuron
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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