- Title
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Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways
- Authors
- Zhang, C., Li, C., Chen, S., Li, Z., Ma, L., Jia, X., Wang, K., Bao, J., Liang, Y., Chen, M., Li, P., Su, H., Lee, S.M., Liu, K., Wan, J.B., He, C.
- Source
- Full text @ Sci. Rep.
The effect of PTS on 6-OHDA-induced dopaminergic (DA) neuron loss in zebrafish. Zebrafish embryos at one day post fertilization were exposed to indicated concentrations of PTS or nomifensine (Nom, used as a positive control) in the presence or absence of 0.25 mM 6-OHDA for 48 h. Then larvae were fixed for whole mount immunostaining with antibody against tyrosine hydroxylase (TH). (A) Representative morphology of DA neurons in the zebrafish brain. TH+ neurons in the diencephalic region are within brackets. (B) Statistical analysis of TH+ neurons in each group of ten fish. Values represent the mean ± SD of at least three independent experiments. Data are expressed as a percentage of the control group. ###P < 0.01 versus control (CTL) group, **P < 0.01 versus 6-OHDA-treated group. PHENOTYPE:
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ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. PHENOTYPE:
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