ZFIN Image: Zhang et al., 2017, Fig. 5

Image

Figure Caption

Fig. 5

The effect of PTS on 6-OHDA-induced dopaminergic (DA) neuron loss in zebrafish.

Zebrafish embryos at one day post fertilization were exposed to indicated concentrations of PTS or nomifensine (Nom, used as a positive control) in the presence or absence of 0.25 mM 6-OHDA for 48 h. Then larvae were fixed for whole mount immunostaining with antibody against tyrosine hydroxylase (TH). (A) Representative morphology of DA neurons in the zebrafish brain. TH⁺ neurons in the diencephalic region are within brackets. (B) Statistical analysis of TH⁺ neurons in each group of ten fish. Values represent the mean ± SD of at least three independent experiments. Data are expressed as a percentage of the control group. ^###P < 0.01 versus control (CTL) group, **P < 0.01 versus 6-OHDA-treated group.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.