ZFIN Image: Zhang et al., 2017, Fig. 5

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Fig. 5

The effect of PTS on 6-OHDA-induced dopaminergic (DA) neuron loss in zebrafish.

Zebrafish embryos at one day post fertilization were exposed to indicated concentrations of PTS or nomifensine (Nom, used as a positive control) in the presence or absence of 0.25?mM 6-OHDA for 48?h. Then larvae were fixed for whole mount immunostaining with antibody against tyrosine hydroxylase (TH). (A) Representative morphology of DA neurons in the zebrafish brain. TH⁺ neurons in the diencephalic region are within brackets. (B) Statistical analysis of TH⁺ neurons in each group of ten fish. Values represent the mean?�?SD of at least three independent experiments. Data are expressed as a percentage of the control group. ^###P?<?0.01 versus control (CTL) group, **P?<?0.01 versus 6-OHDA-treated group.

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