FIGURE

Fig. 1

ID

ZDB-FIG-170830-1

Publication

Rasouli et al., 2017 - Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling

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Fig. 1

Nrg2a is required for cardiac trabeculation in zebrafish.

(a,b) Zebrafish larvae from nrg2a^+/− incrosses were imaged at 120 hpf; lateral view, anterior to the left; scale bars, 0.5 mm. nrg2a^−/− larvae can be recognized by their defective jaws (asterisk in b). (c–k) nrg2a mutants lack cardiac trabeculae. Confocal images (mid-sagittal sections) of larval hearts from Tg(myl7:LIFEACT-GFP);nrg2a^+/− incrosses at 75 (c–e), 120 (f–h) and 168 hpf (i–k); ventricular outer curvature (dashed boxes) magnified in upper right corners; arrows and asterisks indicate trabeculated and non-trabeculated walls, respectively; scale bars, 50 μm.

Expression Data

Genes:	GFP mRFP1
Fish:	s974Tg nrg2a^mn0237Gt/+; s974Tg nrg2a^{mn0237Gt/mn0237Gt}; s974Tg
Anatomical Terms:	atrial endocardium myocardium ventricular endocardium ventricular myocardium
Stage Range:	Protruding-mouth to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nrg2a^{mn0237Gt/mn0237Gt} nrg2a^{mn0237Gt/mn0237Gt}; s974Tg
Observed In:	heart trabecula formation mandibular arch skeleton swim bladder inflation
Stage Range:	Protruding-mouth to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.