FIGURE

Fig. 1

ID

ZDB-FIG-170830-1

Publication

Rasouli et al., 2017 - Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling

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Fig. 1

Nrg2a is required for cardiac trabeculation in zebrafish.

(a,b) Zebrafish larvae from nrg2a^+/? incrosses were imaged at 120?hpf; lateral view, anterior to the left; scale bars, 0.5?mm. nrg2a^?/? larvae can be recognized by their defective jaws (asterisk in b). (c?k) nrg2a mutants lack cardiac trabeculae. Confocal images (mid-sagittal sections) of larval hearts from Tg(myl7:LIFEACT-GFP);nrg2a^+/? incrosses at 75 (c?e), 120 (f?h) and 168?hpf (i?k); ventricular outer curvature (dashed boxes) magnified in upper right corners; arrows and asterisks indicate trabeculated and non-trabeculated walls, respectively; scale bars, 50??m.

Expression Data

Genes:	GFP mRFP1
Fish:	s974Tg nrg2a^mn0237Gt/+; s974Tg nrg2a^{mn0237Gt/mn0237Gt}; s974Tg
Anatomical Terms:	atrial endocardium myocardium ventricular endocardium ventricular myocardium
Stage Range:	Protruding-mouth to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nrg2a^{mn0237Gt/mn0237Gt} nrg2a^{mn0237Gt/mn0237Gt}; s974Tg
Observed In:	heart trabecula formation mandibular arch skeleton swim bladder inflation
Stage Range:	Protruding-mouth to Days 7-13

Phenotype Detail

Acknowledgments

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