FIGURE

Fig. 3

ID

ZDB-FIG-170830-3

Publication

Rasouli et al., 2017 - Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling

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Fig. 3

Reduction of cardiac jelly thickness in developing zebrafish.

(a–h) Mid-sagittal confocal sections of late embryonic and early larval zebrafish hearts. Animals from Tg(kdrl:Hsa.HRAS-mCherry);Tg(myl7:EGFP-Hsa.HRAS) incrosses were synchronized at the tail bud stage (10 hpf) and imaged at 48 (a), 54 (b), 60 (c), 72 (d), 80 (e), 96 (f), 120 (g) and 144 hpf (h); endocardial and myocardial membranes are labelled in red and green, respectively; AV, atrioventricular canal, At, atrium; V, ventricle; scale bars, 50 μm. Higher magnification images of outer curvature area of ventricular (white dashed boxes) and atrial (yellow dashed boxes) walls are shown beneath each time point, respectively. The cardiac jelly is initially thicker in the atrium than in the ventricle at 48 hpf (a). It is greatly reduced in the ventricle by 72 hpf, (b–d) and almost fully gone by 96 hpf, while it is still detectable at 120 hpf in the atrium (e–h); arrowheads point to trabecular cardiomyocytes; arrows and asterisks indicate the presence and absence of cardiac jelly, respectively.

Expression Data

Genes:	EGFP mCherry
Fish:	s883Tg; s896Tg
Anatomical Terms:	atrial endocardium membrane atrial myocardium membrane endocardium membrane myocardium membrane ventricular endocardium membrane ventricular myocardium membrane
Stage Range:	Long-pec to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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