Fig. 1
Nrg2a is required for cardiac trabeculation in zebrafish.
(a,b) Zebrafish larvae from nrg2a+/− incrosses were imaged at 120 hpf; lateral view, anterior to the left; scale bars, 0.5 mm. nrg2a−/− larvae can be recognized by their defective jaws (asterisk in b). (c–k) nrg2a mutants lack cardiac trabeculae. Confocal images (mid-sagittal sections) of larval hearts from Tg(myl7:LIFEACT-GFP);nrg2a+/− incrosses at 75 (c–e), 120 (f–h) and 168 hpf (i–k); ventricular outer curvature (dashed boxes) magnified in upper right corners; arrows and asterisks indicate trabeculated and non-trabeculated walls, respectively; scale bars, 50 μm.