FIGURE

Fig. 4

ID

ZDB-FIG-170815-17

Publication

Lim et al., 2017 - Caveolae Protect Notochord Cells against Catastrophic Mechanical Failure during Development

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Fig. 4

Transverse Ultrastructure of 3-dpf cavin1b^−/− Notochords

Ultrastructure of the junction between two neighboring notochord cells in non-lesion sites from WT (A–C) and cavin1b^−/− (D–F) zebrafish embryos. Higher magnification in (C) shows dense caveolae in the membranes of adjacent cells in WT. Higher magnification in (E) and (F) highlights loss of caveola density in the septa between cavin1b^−/− cells. Black arrowheads indicate caveolae. Note the differences in morphology between 3-dpf WT and cavin1b^−/− caveolae. For quantitation of caveola number and shape description, refer to Figures S4A–S4D. PM, plasma membrane; Vac, vacuole. The scale bars represent (A, B, and D–F) 2 μm and (C) 200 nm. For ultrastructure of skeletal muscle, refer to Figure S4E.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cavin1b^uq7rp/uq7rp
Observed In:	notochord inner cell caveola notochord inner cell caveola bulb notochord inner cell caveola neck notochord inner cell plasma membrane
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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