FIGURE
Fig. S7
- ID
- ZDB-FIG-170609-49
- Publication
- Theodore et al., 2017 - Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization
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Fig. S7
Mmp9 inhibition does not impact HSPC localization in cxcl12a heterozygous mutants. Related to Figure 7. A) Exposure of wild-type (WT) sibling controls to MMP9-I (5μM, 12-72 hpf) increased cmyb expression in the CHT at 72 hpf; in contrast, while heterozygous loss of cxcl12a in cxcl12at30516/t30516 (cxcl12a+/-) embryos had no impact on cmyb expression alone, it antagonized the effect of Mmp9 inhibition (n≥20/condition). B) Qualitative phenotypic distribution of control and MMP9-I treated WT and cxcl12a+/- siblings from S7A scored with high/medium/low cmyb expression at 72 hpf (n≥20/condition). Scale bars: 100μm. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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