FIGURE

Fig. S2

ID

ZDB-FIG-170607-23

Publication

Benedetti et al., 2016 - INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

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Fig. S2

The macroscopic anatomy and body weight of adult zebrafish are not affected by Sod1 over-expression.

(A) Typical traits measured to compare the macroscopic anatomy of the transgenic and Ctrl zebrafish: standard length (SL), the length between the operculum and the caudal peduncle (LOCP), and height at the anterior of the anal fin (HAA). Scale bar: 0.5 cm. (B) Each fish was transversely cut into five segments (S1-S5) using the fins as anatomical references. Scale bar: 0.5 cm. (C) Representative pictures of 12-month-old zebrafish: an adult of the AB line (Ctrl), and zebrafish expressing wtSod1 or mSod1. Scale bar: 0.5 cm. (D) The histograms show SL, HAA, LOCP measured in seven Ctrl, six wtSod1, and seven mSod1 fish, and the body weight recorded in 15 Ctrl, 14 wtSod1, and 14 mSod1 fish. The columns indicate the mean values ± SEM of the indicated parameter, and the results were statistically analyzed using one-way analysis of variance (ANOVA) and the Kruskal-Wallis test, corrected by means of Dunn’s multiple comparison test. There were no significant differences among the three genotypes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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