FIGURE

Fig. 3

ID

ZDB-FIG-161229-15

Publication

Venero Galanternik M. et al., 2016 - Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

glypican4 acts redundantly with other HSPGs in the primordium. (A-B′) Lateral views of sibling (A) and glypican4^fr6 mutant (B) embryos stained for the Wnt/β-catenin target lef1. (A-B) Sibling and glypican4^fr6 mutant embryos show normal expression of lef1 restricted to the leading region of the primordium. (A′-B′) show magnifications of the primordia in (A-B). (C-E′) Lateral views of a sibling (C), a glypican4^+/fr6 heterozygous (D) and a homozygous glypican4^fr6 mutant (E) treated with a suboptimal dose of Sodium Chlorate (100 mM) and stained for lef1. The treatment does not affect expression of lef1 in wild type primordia (C′) but lef1 expression expands in both heterozygous glypican4^+/fr6 and homozygous glypican4^fr6 mutants (D′ and E′).

Expression Data

Gene:	lef1
Fish:	WT gpc4^fr6/fr6 gpc4^fr6/+
Condition:	chemical treatment by environment: sodium chlorate
Anatomical Term:	posterior lateral line primordium
Stage:	High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gpc4^fr6/fr6 gpc4^fr6/+
Condition:	chemical treatment by environment: sodium chlorate
Observed In:	posterior lateral line primordium
Stage:	High-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 419(2), Venero Galanternik M., Lush, M.E., Piotrowski, T., Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously, 321-335, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.