FIGURE

Fig. 6

ID

ZDB-FIG-160308-21

Publication

Nguyen et al., 2016 - Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras(V12) expression in transgenic zebrafish

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Fig. 6

Deregulation of ERK and Wnt/β-catenin pathways in different types of kras^V12-induced liver tumors.

Three types of liver neoplasia including benign HCA, malignant HCC and HB were examined for the expression patterns of P-ERK1/2 and β-catenin via immunohistochemistry. (A,C,E,G) Strong mixed nuclear and cytoplasmic stainings of P-ERK1/2 were detected in three types of kras^V12 liver tumors as compared to control liver of non-induced Triple-Tg fish. (B,D,F,H) Immunohistochemistry for β-catenin showed nuclear localization and accumulation of β-catenin only in HCC and HB, whereas normal liver and HCA displayed membranous staining of β-catenin. Scale bars, 50 µM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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