FIGURE

Fig. 4

ID

ZDB-FIG-160308-20

Publication

Nguyen et al., 2016 - Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras(V12) expression in transgenic zebrafish

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Fig. 4

Heterogeneous liver tumors induced by kras^V12.

Histopathological examinations of liver tumors from Triple-Tg fish induced at 1-month-old. (A,B) Representative normal liver section from Triple-Tg fish without induction. (C,D) Liver tumor from induced Triple-Tg fish after 15 weeks displayed many vacuolated hepatocellular adenoma (HCA) with carcinoma grade 2 (HCC) arising in the center. (E,F) Liver tumor from induced Triple-Tg fish after 19 weeks showed HCC (grade 1) occupying 80% of the liver volume, with HCC (grade 2) arising centrally. (G,H) A Triple-Tg fish at 28 weeks after induction showing HCC (grade 2–3) involving the entire liver with extensive areas of hepatoblastoma (HB). Right panel showed high magnification of boxed area in the left panel. Arrows indicated the boundaries between different types of liver tumors. Scale bars, 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz23Tg/+; gz34Tg/+; gz35Tg/+
Condition:	chemical treatment: mifepristone
Observed In:	liver hepatic tumor liver hepatoblastoma liver hepatocellular adenoma liver hepatocellular carcinoma
Stage Range:	Days 30-44 to Adult

Phenotype Detail

Acknowledgments

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