FIGURE

Fig. 5

ID

ZDB-FIG-151106-24

Publication

Liu et al., 2015 - Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish

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Fig. 5

Knockdown of slc26a2 induces semicircular canal defects in larval zebrafish.

(A) Changes in semicircular canal morphology and cilia size (scale bars = 30 µm). (B) Changes of neuromasts numbers and hair cell numbers in lateral line (scale bars = 20 µm). (C, D) Changes of cilia numbers in the inner ear (scale bars = 20 µm). (D) Statistical analysis of the ciliary bundles in the inner ear in different types of embryos at 120hpf, including wild type(WT), mismatch-MO control, S2-SP1 MO and Rescue. (E) Statistical analysis of the L1-8 neuromasts numbers in the posterior lateral line in different types of embryos at 120hpf, including WT, Mis-con, S2-SP1 and Rescue. (F) Statistical analysis of the hair cells numbers per neuromast in different types of embryos at 120hpf, including WT, Miscon, S2-SP1 and Rescue. ***P<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-slc26a2 s356tTg + MO1-slc26a2
Knockdown Reagent:	MO1-slc26a2
Observed In:	auditory receptor cell stereocilium lateral line neuromast lateral line neuromast hair cell neuromast hair cell semicircular canal somite
Stage:	Day 5

Phenotype Detail

Acknowledgments

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