FIGURE

Fig. S1

ID

ZDB-FIG-150921-33

Publication

Anderson et al., 2015 - In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress

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Fig. S1

Complementation of zebrafish apol1 morphants with other members of the human APOL gene cluster.

(A-E) Human mRNA corresponding to APOL2, APOL3, APOL4, APOL5, and APOL6 (100pg/nl) were each co-injected with apol1 MO and scored for edema at 5 dpf. Ectopic expression of each of the other members of the human APOL gene cluster was unable to rescue significantly the edema formation in developing embryos co-injected with apol1 MO. (F) We observed a novel body axis phenotype in embryos injected with either APOL3 or APOL5 alone, although this did not seem to be relevant to kidney dysfunction. White bars, normal; black bars, edema; grey bars, adverse. C, sham-injected control; NI, non-injected control; n = 32–68 embryos/injection batch; masked scoring.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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