ZFIN Image: Anderson et al., 2015, Fig. S1

Image

Figure Caption

Fig. S1 Complementation of zebrafish apol1 morphants with other members of the human APOL gene cluster.

(A-E) Human mRNA corresponding to APOL2, APOL3, APOL4, APOL5, and APOL6 (100pg/nl) were each co-injected with apol1 MO and scored for edema at 5 dpf. Ectopic expression of each of the other members of the human APOL gene cluster was unable to rescue significantly the edema formation in developing embryos co-injected with apol1 MO. (F) We observed a novel body axis phenotype in embryos injected with either APOL3 or APOL5 alone, although this did not seem to be relevant to kidney dysfunction. White bars, normal; black bars, edema; grey bars, adverse. C, sham-injected control; NI, non-injected control; n = 32–68 embryos/injection batch; masked scoring.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.