FIGURE

Fig. S2

ID

ZDB-FIG-150717-20

Publication

Gallardo et al., 2015 - Phenotype-driven chemical screening in zebrafish for collective cell migration inhibitors identifies multiple potential pathways for targeting metastasis

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Fig. S2

Supplemental figure 2. Chemically induced inflammation (ChIn) assay.

DMSO-treated Tg(mpx:EGFP) larvae show the normal distribution of labeled cells, mostly localized in the ventral trunk and tail (A). In copper-treated siblings (B), leukocytes become localized preferentially to a few clusters along the horizontal midline of the trunk and tail (white arrows). Larvae exposed to indicated compounds (C-H) exhibit a decreasing number of leukocytes along the PLL. Inhibitors (C-H) were added to the incubation medium 30 min prior to addition of copper and were tested for inhibition of leukocyte migration using ChIn assays.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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