FIGURE

Fig. 4

ID

ZDB-FIG-140917-18

Publication

Qin et al., 2014 - Nom1 Mediates Pancreas Development by Regulating Ribosome Biogenesis in Zebrafish

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Fig. 4

Nom1 is indispensable for pancreas proliferation but not for specification.

(A–F) Dorsal views, anterior to the top. (A, B) Expression of prox1 (D, E) and pdx-1 (C, F) in the nom1 morphants is comparable to that in WT embryos at 36 hpf but reduced gata6 expression in liver (arrow) and pancreas (arrowhead) of nom1 morphants is obvious. (G) Anti-phospho Histone H3 (pH 3) staining for control and nom1 morphant embryos at 3 dpf. Red: GFP staining. Green: pH 3 staining. The signal of pH 3 staining in the pancreas of morphants is recognizably decreased. (H) Quantification of pH 3-positive cell numbers. Data were collected from 10 embryos. Error bars mean±SD. **P<0.01.

Expression Data

Genes:	EGFP gata6 pdx1 prox1a
Fish:	TU TU + MO1-nom1 jh1Tg jh1Tg + MO1-nom1
Knockdown Reagent:	MO1-nom1
Anatomical Terms:	endoderm liver pancreas pancreatic bud
Stage Range:	Prim-25 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO1-nom1 jh1Tg + MO1-nom1
Knockdown Reagent:	MO1-nom1
Observed In:	exocrine pancreas cell population proliferation pancreas development pancreas field specification
Stage Range:	Prim-25 to Protruding-mouth

Phenotype Detail

Acknowledgments

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