FIGURE

Fig. 8

ID

ZDB-FIG-140917-19

Publication

Qin et al., 2014 - Nom1 Mediates Pancreas Development by Regulating Ribosome Biogenesis in Zebrafish

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Fig. 8

Nom1-induced pancreas defect is p53 independent.

(A–D) Lateral views, anterior to the left. (A) control group at 3 dpf. (B) dg5 mutant group at 3 dpf. (C) Failure to rescue the pancreas defect by injection of 4 ng p53MO into dg5 mutant or (D) injection of nom1 MO in p53^M214K mutant. (E) Expression of p53 and its targets Δ1113p53 and p21 are increased in dg5^nom1 mutant, as assessed by quantitative PCR. Error bars mean±SD. **P<0.01, *P<0.05.

Expression Data

Gene:	prss1
Fish:	TU nom1^zf591/zf591 nom1^zf591/zf591 + MO4-tp53 tp53^zdf1/zdf1 + MO1-nom1
Knockdown Reagents:	MO1-nom1 MO4-tp53
Anatomical Term:	exocrine pancreas
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nom1^zf591/zf591 nom1^zf591/zf591 + MO4-tp53 tp53^zdf1/zdf1 + MO1-nom1
Knockdown Reagents:	MO1-nom1 MO4-tp53
Observed In:	exocrine pancreas exocrine pancreas development
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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