FIGURE

Fig. 1

ID

ZDB-FIG-140723-17

Publication

DuVal et al., 2014 - Growth differentiation factor 6 as a putative risk factor in neuromuscular degeneration

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Fig. 1

Zebrafish harboring homozygous mutations in gdf6 can be raised to adulthood and do not display overt skeletal defects.

A. gdf6^-/- fish are viable into adulthood, exhibit variably penetrant microphthalmia and normal body morphology. B. gdf6^-/- fish exhibit somewhat decreased survival compared to gdf6^+/+ siblings (n = 11 gdf6^-/- fish; n = 4 gdf6^+/+ siblings). C, D. gdf6^-/- fish lack overt skeletal phenotypes, as revealed by (C) clearing and staining or by (D) microCT analysis. The latter is further represented as Supplemental Movie S1. Scale bars are 5 mm. A variety of fin morphologies were present in the fish examined, but these were neither different between experimental groups (genotypes) nor a significant covariant with swim performance (see Results).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gdf6a^s327/s327
Observed In:	eye
Stage:	Adult

Phenotype Detail

Acknowledgments

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