FIGURE

Fig. 8

ID

ZDB-FIG-140620-3

Publication

Giustiniani et al., 2014 - Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

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Fig. 8

Knockdown of FKBP52 improves larval mobility in HuC-Tau transgenics. (A-C) Tracking analyses of 48-hpf control (WT), Huc-Tau, and Huc-Tau + FKBP52MO larvae in a touch-response test. Each plot line represents the trajectory of one larva after touch stimulation. (D) Quantification of the touch-response test. Each group is divided into three categories: (a) embryos that do not respond at all, (b) embryos that move slightly upon stimulus, and (c) embryos that show a typical escape response. The locomotor defects are significantly improved in Huc-Tau larvae injected with 0.4 pmol of FKBP52 MO (Kruskal-Wallis test,***P < 0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	knu3Tg; mde3Tg knu3Tg; mde3Tg + MO1-fkbp4
Knockdown Reagent:	MO1-fkbp4
Observed In:	thigmotaxis whole organism larval locomotory behavior
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA