FIGURE

Fig. 5

ID

ZDB-FIG-140612-30

Publication

Giustiniani et al., 2014 - Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

FKBP52 modulates pathological Tau activity in spinal primary motoneurons. (A–C) Lateral views of 48-hpf control embryos and FKBP52 morphant. Lateral views of znp1 antibody staining of control (D), FKBP52 morphant (E), Huc-Tau (F), and Huc-Tau injected with either FKBP52 MO (G) or FKBP52 mRNA (H) are shown at 48 hpf. (D2–H2) Tracings of motor-axon tracts ventral to the spinal cord derived from the panels directly above. In all images, anterior is to the left and dorsal is to the top. (Scale bars: A–C, 200 µm; D2–H2, 100 µm.) (I) Bar chart depicts the difference in the percentage of axons that reach their most ventral target. No significant difference is observed between WT and Huc-Tau + FKBP52MO embryos (N.S, P > 0.05; *P < 0.05; **P < 0.01). N.S, nonsignificant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-fkbp4 knu3Tg; mde3Tg knu3Tg; mde3Tg + MO1-fkbp4
Knockdown Reagent:	MO1-fkbp4
Observed In:	CaP motoneuron CaP motoneuron axon neurogenesis whole organism anatomical axis whole organism anterior-posterior axis
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA