FIGURE

Fig. 8

ID

ZDB-FIG-140617-21

Publication

Flasse et al., 2013 - Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish

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Fig. 8

The onset of sox4b expression is delayed in ascl1b morphants and is restricted to neurod1 expressing cells. Ventral views with the anterior part to the left of double fluorescent WISH showing expression of sox4b and neurod1 at 12 hpf (A-F), 13 hpf (G-L) and 17 hpf (M-R) in control and ascl1b morphants. The domain occupied by sox4b+ and neurod1+ cells was reduced respectively 3.3- and 2.6-fold in the Mo-ascl1b at 17 hpf. The arrows point to a cell expressing sox4b and neurod1 while the arrowheads points to a cell expressing only sox4b. Z-plane confocal images. Scale bars : 50 µm hpf, hours post fertilization; WISH, whole-mount in situ hybridization.

Expression Data

Genes:	neurod1 sox4b
Fish:	WT WT + MO1-ascl1b
Knockdown Reagent:	MO1-ascl1b
Anatomical Terms:	pancreas primordium trunk embryonic structure
Stage Range:	5-9 somites to 10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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