FIGURE

Fig. 2

ID
ZDB-FIG-140522-7
Publication
Nissim et al., 2014 - Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth
Other Figures
All Figure Page
Back to All Figure Page
Fig. 2

PGE2 Affects Embryonic Pancreas Outgrowth (A) In situ hybridization for trypsin, an exocrine pancreas-specific marker, following exposure to dmPGE2 or Indo reveals that embryonic pancreas size is regulated by PGE2. dmPGE2 increases exocrine pancreas size (57.6% embryos with an enlarged pancreas; n = 38/66), whereas Indo diminishes exocrine pancreas size (70.6% embryos with a smaller pancreas; n = 36/51). Dorsal view. (B) FACS quantification of GFP+ exocrine pancreas cells in elastase:GFP embryos at 96 hpf following exposure to dmPGE2 or Indo. dmPGE2 increases and Indo decreases the relative number of exocrine pancreas cells. (Data are represented as mean ± SEM; ****significant across treatment groups, ANOVA, p < 0.0001.)

Expression Data
Genes:
Fish:
Conditions:
Knockdown Reagents:
Anatomical Terms:
Stage Range: Protruding-mouth to Day 4

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Conditions:
Knockdown Reagents:
Observed In:
Stage Range: Protruding-mouth to Day 4

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 28(4), Nissim, S., Sherwood, R.I., Wucherpfennig, J., Saunders, D., Harris, J.M., Esain, V., Carroll, K.J., Frechette, G.M., Kim, A.J., Hwang, K.L., Cutting, C.C., Elledge, S., North, T.E., and Goessling, W., Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth, 423-437, Copyright (2014) with permission from Elsevier. Full text @ Dev. Cell