FIGURE

Fig. 8

ID

ZDB-FIG-140306-9

Publication

Reifers et al., 1998 - Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis

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Fig. 8

Fgf8 is required for the maintenance of MHB marker genes. Lateral views of dissected brain primordia. Stages and markers as indicated. (A-F) Expression of Pax2.1 in wild-type (A-C) and acerebellar (D-F) embryos. Notice the gradual reduction in width at the MHB in B, E, and the reduction of otic placode (A,D), optic stalk and anterior hindbrain expression in C versus F. (G-L) Expression of Her5 in wild-type (G-I) and acerebellar (J-L) embryos. Expression of Eng2 in wild-type (M-O) and acerebellar (P-R) embryos. Arrowheads depict the width of the MHB, brackets mark anterior hindbrain. op, otic placode.

Expression Data

Genes:	en2a her5 pax2a
Fish:	WT fgf8a^{ti282a/ti282a}
Anatomical Terms:	hindbrain anterior region midbrain hindbrain boundary midbrain hindbrain boundary neural keel optic cup optic stalk optic vesicle otic placode
Stage Range:	5-9 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf8a^{ti282a/ti282a}
Observed In:	midbrain hindbrain boundary midbrain-hindbrain boundary development
Stage Range:	5-9 somites to Prim-5

Phenotype Detail

Acknowledgments

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