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Fig. 8 Fgf8 is required for the maintenance of MHB marker genes. Lateral views of dissected brain primordia. Stages and markers as indicated. (A-F) Expression of Pax2.1 in wild-type (A-C) and acerebellar (D-F) embryos. Notice the gradual reduction in width at the MHB in B, E, and the reduction of otic placode (A,D), optic stalk and anterior hindbrain expression in C versus F. (G-L) Expression of Her5 in wild-type (G-I) and acerebellar (J-L) embryos. Expression of Eng2 in wild-type (M-O) and acerebellar (P-R) embryos. Arrowheads depict the width of the MHB, brackets mark anterior hindbrain. op, otic placode.