FIGURE

Fig. 5

ID

ZDB-FIG-140214-42

Publication

Valvezan et al., 2014 - Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1)

Other Figures

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Fig. 5

Combined inhibition of mTORC1 and Wnt signaling reduces body curvature in apc^mcr/mcr zebrafish. (A) Representative images of apc^mcr/mcr zebrafish at 2 dpf treated with vehicle, Torin1 (250 nM), XAV939 (500 nM) or Torin1 plus XAV939. Combined Torin1 and XAV939 treatment rescued body curvature whereas either treatment alone did not. (B) Zebrafish were scored at 2-3 dpf on the basis of severity of body curvature; the percentage of fish in each category is shown. Only combined Torin1 plus XAV939 treatment reduced body curvature. (C) Rapamycin also reduced body curvature in combination with XAV939, but not by itself. (D) Representative pictures of each of the three categories used to score body curvature in B and C.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apc^hu745/hu745
Observed In:	anterior/posterior axis specification whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.