FIGURE

Fig. 6

ID

ZDB-FIG-131220-4

Publication

Lu et al., 2013 - Liver-Specific Expressions of HBx and src in the p53 Mutant Trigger Hepatocarcinogenesis in Zebrafish

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Fig. 6

(A1) H&E staining of liver sections from wild-type fish revealed normal histology at 11 months. (A2~A6) H&E staining of liver sections from src-overexpressing, wild-type fish displayed steatosis, hyperplasia, dysplasia and HCC at 11 months. (B1) H&E staining of liver sections from the p53 mutant fish showed normal features at 11 months. (B2~B6) H&E staining of liver sections from src(p53^-) transgenic fish showed severe steatosis and chronic inflammation, dysplasia, HCC and sarcomatoid HCC at 11 months. (C) The hepatocytes from the double transgenic line overexpressing HBx and src in a wild-type background exhibit steatosis, chronic inflammation, hyperplasia, and HCC. All sections were stained with H&E and photographed at 400X magnification. Scale bars: 50 μm. A7, B7, and C4 show the statistical analysis of the H&E staining results. The following different colors denote the different pathological features: gray-normal, purple-chronic inflammation, blue-steatosis, light blue-bile duct dilation, green-hyperplasia, yellow-dysplasia, and red-HCC.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nn1003Tg nn1001Tg; nn1003Tg tp53^zdf1/zdf1; nn1004Tg
Observed In:	common bile duct hepatocyte hepatocyte mitotic cell cycle hepatocyte nucleolus hepatocyte nucleus liver liver hepatic tumor
Stage:	Adult

Phenotype Detail

Acknowledgments

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