FIGURE

Fig. S1

ID

ZDB-FIG-131210-30

Publication

Balow et al., 2013 - Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome

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Fig. S1

Sectioning of chd7 morphants reveals moderate to severe craniofacial cartilage abnormalities. (A–C) Alcian blue cartilage staining of 10 μm sectioned zebrafish embryos at 4 dpf. Staining revealed wild-type structures of Std morphants (A), while chd7 morphants (B–C) had many of the cartilaginous structures absent. Sectioning confirmed the common chd7 morphant phenotype does not develop all of the ceratobranchial cartilages (B). Staining of severe chd7 morphants only detected some development of the neurocranium (C). AC=auditory capsule, CB=ceratobranchial, CH=ceratohyal, EP=ethmoid plate, ME=Meckel′s cartilage, PC=parachordal, PQ=palatoquadrate, and T=trabeculacranii.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO3-chd7
Knockdown Reagent:	MO3-chd7
Observed In:	ceratobranchial cartilage cranial cartilage neurocranium
Stage:	Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 382(1), Balow, S.A., Pierce, L.X., Zentner, G.E., Conrad, P.A., Davis, S., Sabaawy, H.E., McDermott, B.M., and Scacheri, P.C., Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome, 57-69, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.