FIGURE

Fig. 8

ID

ZDB-FIG-131024-15

Publication

Kamel et al., 2013 - Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

Overexpression of bapx1 partially rescues lower jaw elements in wnt9a, frzb and fzd7a morphants. Live embryo morphology (A–C) and Alcian blue cartilage stain (D–F) at 10× magnification, lower jaw flatmount at 20× magnification (G–I). Anterior is to the left in all images. Overexpression of bapx1 mRNA in wnt9a, frzb and fzd7a morphants partially rescued distal palatoquadrate and Meckel′s cartilage elements (arrowhead, D–F, G–I). Graphs summarize the representative phenotypes, where the total number of embryos scored for wildtype (red bar) and morphant phenotypes (blue bar) are shown with 5% error bars (L–N). Overexpression of wnt9a, frzb and fzd7a in HEK293T cells increased Bapx1 protein production as shown by Western blot (J) where actin serves as an internal control and Flag represents mammalian expression vector tag. Bapx1 expression was increased in a statistically significant manner, P<0.05 (K). Abbreviations: M (Meckel′s cartilage), pq (palatoquadrate)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 381(2), Kamel, G., Hoyos, T., Rochard, L., Dougherty, M., Tse, W., Shubinets, V., Grimaldi, M., and Liao, E.C., Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis, 423-33, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.