FIGURE

Fig. 1

ID

ZDB-FIG-130801-1

Publication

Teslaa et al., 2013 - Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development

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Fig. 1

Zic2 is required for craniofacial development. Alcian blue-stained cartilage in zic2 morphants at 5 dpf. (A,D) Control morphants have wild-type pharyngeal and neurocranial cartilages (53/55, 6 exp.). (B) Zic2a morphants have variable craniofacial defects, including hypoplastic pharyngeal cartilages and an incorrectly angled hyoid arch (16/54, 5 exp.; outline in 1B′). (E) Severely affected zic2a morphants have more dramatic hypoplasia (10/54, 5 exp.) or ablation of anterior cartilages (11/54, not shown). (C,F) Zic2b morphants are either wild-type (45/70, 6 exp.) or develop shortened mandibular and hyoid arches (25/70, 6 exp.). (G) Penetrance of craniofacial defects in control and morphant embryos. (A–C) are dorsal views with anterior to the left. (D–F) are lateral views. Abbreviations: cb—ceratobranchials, h—hyoid, m—mandibular, nc—neurocranium.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-zic2b WT + MO3-zic2a
Knockdown Reagents:	MO2-zic2b MO3-zic2a
Observed In:	embryonic viscerocranium morphogenesis pharyngeal arch 2 pharyngeal arch cartilage ventral mandibular arch
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 380(1), Teslaa, J.J., Keller, A.N., Nyholm, M.K., and Grinblat, Y., Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development, 73-86, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.