FIGURE

Fig. 7

ID

ZDB-FIG-130627-43

Publication

Stuckenholz et al., 2013 - Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio

Other Figures

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Fig. 7

Modulation of sfrp5 expression causes defects in gastrointestinal development.

A–P) Dorsal views of 3 dpf old embryos stained with probes against fabp10a (A–D), anxa2b (E–H), try (I–L), and ins (M–O). Embryos were injected with 0.5 pmol mismatch morpholino (A, E, I, M), 0.5 pmol morpholino against sfrp5 (B, F, J, N), 100 pg eGFP mRNA (C, G, K, O) or 50 pg sfrp5 mRNA (D, H, L, P). Q) Chart summarizing in situ results (A–L), showing percentages of normal or small GI organs. R) Chart summarizing in situ results (M–P), showing the percentage of larvae in which ins⁺ cells failed to coalesce. The total number of analyzed embryos per treatment is shown below each column.

Expression Data

Genes:	anxa2b fabp10a ins prss1
Fish:	WT WT + MO1-sfrp5
Knockdown Reagent:	MO1-sfrp5
Anatomical Terms:	endocrine pancreas exocrine pancreas intestine liver
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-sfrp5
Knockdown Reagent:	MO1-sfrp5
Observed In:	intestine liver pancreas
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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