FIGURE

Fig. S6

ID

ZDB-FIG-130625-34

Publication

Schmid et al., 2013 - Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

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Fig. S6

Ultrastructural morphology of myocytes in tardbp^-/-;tardbpl^-/- mutants analyzed by EM and early lethality. (A) Skeletal muscles of a wild-type embryo display an ordered array of myofibrils surrounded by a highly ordered network of sarcoplasmic reticulum (here shown in cross-sections). Each of the myofibrils is clearly separated by a string of sarcoplasmic reticulum. (B) Skeletal muscle of a tardbp^-/-;tardbpl^-/- mutant embryo shows a highly disorganized pattern of thinner myofibrils with disorganized network of sarcoplasmic reticulum at 2 dpf.. (Scale bars, 2 μm.) n = nucleus. (C) Kaplan–Meier plot of wild-type (green) and tardbp^-/-;tardbpl^-/- mutant (purple) embryos. All tardbp^-/-;tardbpl^-/- mutant embryos analyzed were dead by 8 dpf (n = 20), whereas all wildtype embryos were alive (n = 20).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA