FIGURE

Fig. 1

ID

ZDB-FIG-130507-7

Publication

Basten et al., 2013 - Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas

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Fig. 1

Heterozygous lrrc50^Hu255h zebrafish are predisposed to testicular tumor formation.

(A) Incidences of tumors extracted from randomly selected male controls derived from ENU-mutagenesis (n = 104) and heterozygote male lrrc50^Hu255h (n = 30) zebrafish between 24–44 months of age are summarized in pie charts. Tumor formation presented as both TGCT and non-TGCT (sporadic tumors in somatic tissues) in the lrrc50^Hu255h cohort (90%) is significantly elevated from TGCT (16.3%) formation in the controls (P<0.0001). No alternative tumor types were noticeable in the control group. (B) An age-matched wild-type zebrafish compared to a TGCT bearing lrrc50+/ zebrafish (skin around tumor removed; merge of three images). (C) Wild-type testes are composed of two tubular arms forming the paired gonad. The tissue architecture is severely disrupted in the tumor.

Expression Data

Gene:	piwil1
Antibody:	Ab1-piwil1
Fish:	WT dnaaf1^hu255H/+
Anatomical Term:	spermatogonium
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dnaaf1^hu255H/+
Observed In:	testis germ cell tumor testis seminoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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