IMAGE

Fig. 1

ID

ZDB-IMAGE-130507-7

Genes

piwil1

Antibodies

Ab1-piwil1

Source

Figures for Basten et al., 2013

Image

Figure Caption

Fig. 1

Heterozygous lrrc50^Hu255h zebrafish are predisposed to testicular tumor formation.

(A) Incidences of tumors extracted from randomly selected male controls derived from ENU-mutagenesis (n = 104) and heterozygote male lrrc50^Hu255h (n = 30) zebrafish between 24–44 months of age are summarized in pie charts. Tumor formation presented as both TGCT and non-TGCT (sporadic tumors in somatic tissues) in the lrrc50^Hu255h cohort (90%) is significantly elevated from TGCT (16.3%) formation in the controls (P<0.0001). No alternative tumor types were noticeable in the control group. (B) An age-matched wild-type zebrafish compared to a TGCT bearing lrrc50+/ zebrafish (skin around tumor removed; merge of three images). (C) Wild-type testes are composed of two tubular arms forming the paired gonad. The tissue architecture is severely disrupted in the tumor.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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