FIGURE

Fig. 5

ID

ZDB-FIG-130326-48

Publication

Djiotsa et al., 2012 - Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Pax4 is not required for β-cell differentiation. (A - J) Ventral views of the pancreas area from embryos analyzed by WISH, anterior to the left. Pancreatic expression of insulin (A, B), somatostatin (C, D), ghrelin (E, F), glucagon (G, H) and arx (I, J) in control morphants (A, C, E, F, I) and pax4 morphants (B, D, F, G, J) at 30 hpf. Quantifications (K, L, M, N) represent the number of positive cells per embryo for control morphants and pax4 morphants. Asterisks (*) indicate that the difference between cell number in control morphants and pax4 morphants is statistically significant by Student’s t-test (**: P<0.003; ***: P<0.0001). Original magnification 400x.

Expression Data

Genes:	arxa gcga ghrl ins sst2
Fish:	WT WT + MO1-pax4
Knockdown Reagent:	MO1-pax4
Anatomical Terms:	D cell ghrelin secreting cell glucagon secreting cell insulin secreting cell pancreatic A cell pancreatic B cell pancreatic bud pancreatic epsilon cell posterior pancreatic bud somatostatin secreting cell
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-pax4
Knockdown Reagent:	MO1-pax4
Observed In:	ghrelin secreting cell glucagon secreting cell pancreatic A cell pancreatic epsilon cell
Stage:	Prim-15

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.