FIGURE

Fig. 8

ID

ZDB-FIG-130103-20

Publication

Ernst et al., 2012 - Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish

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Fig. 8

Shroom3 overexpression counteracts the loss of rosettes induced by FGFR inhibitor treatment. (A-H′′) Images of the pLLP in heat-shocked non-transgenic siblings (A-B′,E-F′), hsp70l:shr3v1-tagRFP (C-D′′) or hsp70l:shr3v2-tagRFP (G-H′′) zebrafish embryos treated with DMSO (A,C,E,G) or with 5 μM SU5402 for 4 hours (B,D,F,H). Treatment with 5 μM of SU5402 for 4 hours leads to a loss of apically constricted rosettes (compare B,F with A,E). Induction of shr3v1 (C,D) or shr3v2 (G,H) expression upon heat-shock blocks the loss of rosettes induced by SU5402 treatment (D,H). (I,J) Boxplots displaying the quantification of this experiment by the rosette detector for shr3v1 (I) and shr3v2 (J). Arrowheads indicate centres of apically constricted rosettes. Scale bars: 50 μm.

Expression Data

Gene:	GFP
Fish:	zf106Tg m1275Tg; zf106Tg m1274Tg; zf106Tg zf106Tg; zf115Tg
Conditions:	chemical treatment: SU5402 chemical treatment: SU5402, heat shock
Anatomical Term:	posterior lateral line primordium
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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