FIGURE

Fig. 8

ID

ZDB-FIG-120627-32

Publication

Porreca et al., 2012 - Zebrafish bcl2l is a survival factor in thyroid development

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Fig. 8

Activation of an apoptotic program in the thyroid primordium of bcl2l, pax2a or nk2.1a morphant embryos. Thyroid and apoptotic cells are stained with hhex riboprobe and active-caspase-3 antibody. Lateral (A) and (B) and ventral views (C) and (D) with anterior to the left, and cross sections (E) and (F) with anterior to the top, of 40 hpf embryos. Experimental morpholino is indicated bottom right, stage bottom left and markers on the left. (A) and (B) Embryos injected with control MO (A) or with bcl2l MO (B). (C) and (D) Embryos injected with control MO (C) or pax2a MO (D) deprived of yolk and flattened on their ventral side. (C′), (D′) Magnification of thyroid primordium in (C) and (D). (E) and (F) Embryos injected with control MO (E) or nk21a MO (F). Arrow indicates active-caspase-3 positive cells in the thyroid primordium.

Expression Data

Gene:	hhex
Fish:	WT WT + MO1-bcl2l1 WT + MO1-nkx2.4b WT + MO3-pax2a
Knockdown Reagents:	MO1-bcl2l1 MO1-nkx2.4b MO3-pax2a
Anatomical Term:	thyroid primordium
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 366(2), Porreca, I., De Felice, E., Fagman, H., Di Lauro, R., and Sordino, P., Zebrafish bcl2l is a survival factor in thyroid development, 142-152, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.