FIGURE

Fig. 4

ID

ZDB-FIG-120627-28

Publication

Porreca et al., 2012 - Zebrafish bcl2l is a survival factor in thyroid development

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Fig. 4

bcl2l expression in the thyroid is positively regulated bypax2a,nk2.1aandhhex. Lateral views with anterior to the left. Stage is indicated at bottom left, genotype or experimental morpholino at bottom right and marker at top right. (A) and (B) bcl2l expression in wild-type (A) and in noi^tu29 embryo (B) showing that bcl2l is not expressed in thyroid primordium when pax2a mRNA translation is inhibited. (C) nk2.1a expression in noi^tu29 embryo shows the presence of the thyroid primordium at this stage. (D) and (E) bcl2l expression in control (D) and nk2.1a morphant embryos (E) showing lack of bcl2l expression in the thyroid of a morphant embryo. Hhex (F) and pax2a (G) expression in nk2.1a morphant embryos shows the presence of the thyroid primordium at this stage. (H) and (I) bcl2l expression in control (H) and hhex morphant embryos (I) showing lack of bcl2l expression in the morphant embryo thyroid primordium. Nk2.1a (J) and pax2a (K) expression in hhex morphant embryos shows the presence of the thyroid primordium at the analyzed stage. Arrow indicates the thyroid primordium; asterisk the hindbrain–mindbrain boundary.

Expression Data

Genes:	bcl2l1 hhex nkx2.4b pax2a
Fish:	WT pax2a^tu29a/tu29a WT + MO1-nkx2.4b WT + MO2-hhex
Knockdown Reagents:	MO1-nkx2.4b MO2-hhex
Anatomical Term:	thyroid primordium
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pax2a^tu29a/tu29a
Observed In:	brain midbrain hindbrain boundary
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 366(2), Porreca, I., De Felice, E., Fagman, H., Di Lauro, R., and Sordino, P., Zebrafish bcl2l is a survival factor in thyroid development, 142-152, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.