FIGURE

Fig. 4

ID

ZDB-FIG-120601-50

Publication

Chu et al., 2012 - Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish

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Fig. 4

Tg(krt4:Hsa.myrAkt1)^cy18 fish display obese phenotype at the adult stage.

Comparison of the conditional factor between WT (black) and Tg (red) for either male (A) or female (B) fish aged from 3- to 5-month old. Error bars labeled with stars indicate significant differences as tested by Student’s t-test. Oil Red O stains of fish from either wild-type (C), F0 founder carrying krt4:myrAkt1transgene (D), F1 Tg aged at 3 mpf (E), and F1 Tg aged at 12 mpf (F). Nile red vital staining reveals the lipid accumulation in WT and Tg aged at 7 dpf (G and H), 14 dpf (I and J), 21 dpf (K and L), 28 dpf (M and N) and 35 dpf (O and P). Arrows indicate nile red-positive lipids.WT, wild type; Tg, Tg(krt4:Hsa.myrAkt1)^cy18; dpf, day post-fertilization; mpf, month post-fertilization.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cy18Tg
Observed In:	adipose tissue caudal fin adipose tissue hypodermis adipose tissue pleuroperitoneal cavity adipose tissue positive regulation of growth rate
Stage Range:	Days 7-13 to Adult

Phenotype Detail

Acknowledgments

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