FIGURE

Fig. 5

ID

ZDB-FIG-120517-5

Publication

Gongal et al., 2011 - Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning

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Fig. 5

RA rescues hmx4 morphant phenotypes. Eye field narrowing (A–D), the neural tube closure defect (F–I), and loss of vagal motor neurons (K–N) in hmx4 morphants are rescued by treatment with 1 nM RA. Frequencies of morphant phenotypes are scored for eye field narrowing (E), open neural tube (J) and loss of vagal motor neurons (O). All rescues are statistically significant (see text for statistical tests). Error bars represent standard error.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-hmx4 + MO2-hmx4 + MO4-tp53 rw0Tg + MO1-hmx4 + MO2-hmx4 + MO4-tp53
Knockdown Reagents:	MO1-hmx4 MO2-hmx4 MO4-tp53
Observed In:	eye neural tube vagal lobe motor neuron
Stage Range:	14-19 somites to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 355(1), Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., and Waskiewicz, A.J., Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning, 55-64, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.