FIGURE

Fig. 2

ID

ZDB-FIG-120517-2

Publication

Gongal et al., 2011 - Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning

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Fig. 2

Hmx4 deficient embryos have a narrowed eye field and open neural tube. (A–B) hmx4 morphants have a strongly narrowed eye field, shown at 3 dpf. (C–D) The neural tube fails to close in hmx4 morphants, shown at 18 hpf. hmx4 morphants have (E–F) small otic vesicles, (G–H) a loss of pectoral fins, and (I–J) a reduction in vagal motor neurons (underlined in white), assessed in the Tg(isl1:gfp) line at 3 dpf.

Expression Data

Gene:	GFP
Fish:	rw0Tg + MO1-hmx4 + MO2-hmx4 + MO4-tp53
Knockdown Reagents:	MO1-hmx4 MO2-hmx4 MO4-tp53
Anatomical Term:	motor neuron
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-hmx4 + MO2-hmx4 + MO4-tp53
Knockdown Reagents:	MO1-hmx4 MO2-hmx4 MO4-tp53
Observed In:	eye neural tube otic vesicle pectoral fin
Stage Range:	14-19 somites to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 355(1), Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., and Waskiewicz, A.J., Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning, 55-64, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.