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Fig. 2
Hmx4 deficient embryos have a narrowed eye field and open neural tube. (A–B) hmx4 morphants have a strongly narrowed eye field, shown at 3 dpf. (C–D) The neural tube fails to close in hmx4 morphants, shown at 18 hpf. hmx4 morphants have (E–F) small otic vesicles, (G–H) a loss of pectoral fins, and (I–J) a reduction in vagal motor neurons (underlined in white), assessed in the Tg(isl1:gfp) line at 3 dpf.
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Reprinted from Developmental Biology, 355(1), Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., and Waskiewicz, A.J., Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning, 55-64, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.