FIGURE

Fig. S5

ID

ZDB-FIG-111102-20

Publication

Gore et al., 2011 - Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3

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Fig. S5

Rspo1-Wnt-vegfc signaling does not interact with Notch signaling. Vascular Notch signaling is not affected in rspo1 MO-injected animals. (A,B) Expression of mCherry in the mid-trunk of 24 hpf Tg(T2KTp1bglob:hmgb1-mCherry)^jh11 transgenic Notch reporter embryos (Parsons et al., 2009) injected with either control MO (A) or rspo1 MO (B). Notch-dependent expression of mCherry in the vasculature (arrows) is unchanged in rspo1 MO- compared with control MO-injected animals. The expression of vegfc is not affected by ubiquitous heatshock-inducible transgenic activation of Notch signaling. (C,D) In situ hybridization of the mid-trunk of 24 hpf wild-type sibling embryos (C) or Tg(hsp70:Gal4)^1.5kca4, Tg(UAS:myc-notch1a-intra)^kca3 double transgenic embryos for heatshock-inducible activation of Notch signaling (D), as described previously by Lawson et al. (Lawson et al., 2001). Vascular expression of vegfc (arrows) is unchanged in Notch-activated embryos when compared with their control siblings. Lateral views, anterior towards the left.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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