FIGURE

Fig. 5

ID

ZDB-FIG-110926-15

Publication

Klaassen et al., 2011 - Synaptic transmission from horizontal cells to cones is impaired by loss of connexin hemichannels

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Fig. 5

Horizontal cell properties in wild-type and mutant zebrafish.

(A) I_hemi in wild-type (black) and mutants (red) differ significantly. Whole cell currents of a dissociated horizontal cell when stepped to 60 mV and +60 mV, respectively. In the mutant, the inward Ihemi at 60 mV is reduced, whereas the outward current at +60 mV is enhanced. (B) IV relation of Ihemi in wild-type and mutants. Ihemi is minimally affected around VHC in the dark (30 mV, arrow), is reduced at negative potentials, and is increased at positive potentials. (C) Responses to 500 ms flashes of 200 µm spot and full-field stimuli. The spot/full-field ratio did not differ between wild-type and mutant. (D) Distribution of horizontal cell classes in wild-type and in mutant fish did not differ significantly. (E) Three examples of spectrally coded horizontal cell responses in wild-type and mutants. The retina was stimulated with 500 ms full-field flashes of 624, 525, and 465 nm light.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gja9a^{hu1795/hu1795}
Observed In:	gap junction hemi-channel activity horizontal cell connexin complex
Stage:	Adult

Phenotype Detail

Acknowledgments

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