FIGURE

Fig. 6

ID

ZDB-FIG-110909-17

Publication

Poulain et al., 2011 - Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development

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Fig. 6

Swim bladder formation requires Wnt2, Wnt2bb and Fzd5 activity. foxa1 (A-E) and agr2 (F-I) expression at 48 hpf shows that the swim bladder (outlined by dashed line) is variably reduced in MO-wnt2 (B,G), prt/wnt2bb (C,H) MO-fzd5 (E) and absent in MO-wnt2;prt/wnt2bb embryos (bracket, D,I) compared with controls (A,A2,F,F2). Dorsal views, anterior to top. (J) Proliferation rates in controls, prt/wnt2bb and MO-wnt2 embryos determined by Tg(XlEef1a1:GFP)^s854 and BrdU labelling at 42 hpf. Data are mean±s.e.m. P values are shown (^**P<0.005); n>13 embryos. L, liver; sb, swim bladder.

Expression Data

Gene:	foxa1
Fish:	WT wnt2bb^s403/s403 wnt2bb^s404/s404 WT + MO1-fzd5 WT + MO3-wnt2 wnt2bb^s403/s403 + MO3-wnt2 wnt2bb^s404/s404 + MO3-wnt2
Knockdown Reagents:	MO1-fzd5 MO3-wnt2
Anatomical Terms:	gut liver swim bladder bud
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wnt2bb^s403/s403 wnt2bb^s404/s404 WT + MO1-fzd5 WT + MO3-wnt2 wnt2bb^s403/s403 + MO3-wnt2 wnt2bb^s404/s404 + MO3-wnt2
Knockdown Reagents:	MO1-fzd5 MO3-wnt2
Observed In:	cell population proliferation liver swim bladder swim bladder development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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