FIGURE

Fig. 3

ID

ZDB-FIG-110909-14

Publication

Poulain et al., 2011 - Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development

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Fig. 3

Excess wnt2bb promotes liver formation at the expense of the ventral pancreas. (A-D2) Transient wnt2bb-overexpression in Tg(XlEef1a1:GFP)^s854 (A-B2) and Tg(ptf1a:eGFP)^jh1 (C-D2) embryos at 18 hpf alters foregut patterning resulting in an enlarged liver domain as visualised by Prox1 staining at 28 hpf (B, bracket: B2) and 48 hpf (D,D2). The pancreatic islet (asterisk) serves as landmark to visualize the posterior expansion of hepatoblast domain. (E-H) cp expression at 44 hpf (F) and Tg(fabp10:dsRed)^gz4 expression at 74 hpf (H) indicate ectopic hepatic tissue differentiation in embryos with excess wnt2bb. Excess wnt2bb results in a severe decrease of pancreatic Tg(ptf1a:eGFP)^jh1 (p: arrow, D) and Tg(ela3l:EGFP)^gz2 expression (arrowhead, H). (A-D2,G,H) Ventral views of projections of confocal stacks; (E,F) dorsal views; all anterior towards the top.

Expression Data

Genes:	cp DsRed EGFP GFP
Antibody:	Ab3-prox1
Fish:	WT jh1Tg s854Tg gz2Tg; gz4Tg
Anatomical Terms:	digestive system endoderm liver liver primordium pancreas
Stage Range:	Prim-5 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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