FIGURE

Fig. 4

ID

ZDB-FIG-110712-75

Publication

Gregory-Evans et al., 2011 - Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma

Other Figures

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Fig. 4

Representative images of the effect of diferuloylmethane on TUNEL-labeling in noi mutant larvae at 6 dpf. A: TUNEL-labeling in wholemount larvae (left) and wholemount eye (right) of wildtype zebrafish (wt). B: Extensive TUNEL labeling in larvae and eye of untreated noi mutant zebrafish. C: noi mutant larvae treated with 5 μM diferuloylmethane. D: noi larvae treated with 300 μM zVAD-fmk. Arrow points to optic fissure closure defect delineated by black dotted line. Scale bar whole eye=200 μm; scale bar larval fish=500 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pax2a^tu29a/tu29a
Conditions:	chemical treatment by environment: curcumin chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F
Observed In:	closure of optic fissure eye apoptotic process optic fissure whole organism apoptotic process
Stage:	Day 6

Phenotype Detail

Acknowledgments

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